LncRNAs regulate cancer metastasis via binding to functional proteins

Liting Yang; Yanyan Tang; Fang Xiong; Yi He; Fang Wei; Shanshan Zhang; Can Guo; Bo Xiang; Ming Zhou; Ni Xie; Xiaoling Li; Yong Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng

doi:10.18632/oncotarget.22840

LncRNAs regulate cancer metastasis via binding to functional proteins

Oncotarget. 2017 Dec 1;9(1):1426-1443. doi: 10.18632/oncotarget.22840. eCollection 2018 Jan 2.

Authors

Liting Yang^{1

2

3}, Yanyan Tang², Fang Xiong¹, Yi He^{2

4}, Fang Wei², Shanshan Zhang¹, Can Guo², Bo Xiang², Ming Zhou², Ni Xie⁵, Xiaoling Li², Yong Li^{2

6}, Guiyuan Li^{1

2

3}, Wei Xiong^{1

2

3}, Zhaoyang Zeng^{1

2

3}

Affiliations

¹ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
⁵ Core Laboratory, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
⁶ Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Abstract

Cancer is one of the leading causes of death worldwide, and metastasis is a crucial characteristic of malignancy. Recent studies have shown that lncRNAs play an important role in regulating cancer metastasis through various molecular mechanisms. We briefly summarize four known molecular functions of lncRNAs, including their role as a signal, decoy, guide and scaffold. No matter which pattern lncRNAs follow to carry out their functions, the proteins that lncRNAs bind to are important for them to exhibit their gene-regulating properties. We further illustrate that lncRNAs regulate the localization, stabilization or modification of their binding proteins to realize the binding role of lncRNAs. In this review, we focus on the interactions between lncRNAs and their binding proteins; moreover, we focus on the mechanisms of the collaborative work of lncRNAs and their binding proteins in cancer metastasis, thus evaluating the potential of lncRNAs as prospective novel therapeutic targets in cancer.

Keywords: functional proteins; lncRNA; localization; metastasis; stabilization.

Publication types

Review