Escherichia coli Complications in Pediatric Critical Care

Abstract

Escherichia coli is a bacterium that is an important part of the intestinal tract; however, it has the potential to become pathogenic. Shiga toxin-producing E coli (STEC) is a leading cause of E coli infections and has led to outbreaks in North America. Transmission is through ingestion of contaminated food sources, and via infected humans and animals. Young children infected with STEC are at high risk for developing hemolytic uremic syndrome (HUS). HUS is a clinical syndrome characterized by macroangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Early diagnosis and supportive treatment of HUS are essential to limit complications.

Keywords: Children; Diarrhea; E coli; Enterohemorrhagic E coli (EHEC); Escherichia coli; HUS; Hemolytic uremic syndrome; Shiga toxin–producing E coli (STEC).