Asymmetric mesoporous silica nanoparticles as potent and safe immunoadjuvants provoke high immune responses

Chem Commun (Camb). 2018 Feb 20;54(16):2020-2023. doi: 10.1039/c8cc00327k.

Abstract

Asymmetric mesoporous silica nanoparticles with a head-tail structure are potent immunoadjuvants for delivering a peptide antigen, generating a higher antibody immune response in mice compared to their symmetric counterparts.

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / chemistry*
  • Adjuvants, Immunologic / pharmacokinetics
  • Animals
  • Antibodies / immunology*
  • Antigen-Antibody Reactions
  • Cell Survival
  • HEK293 Cells
  • Humans
  • Mice
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Particle Size
  • Peptides / administration & dosage*
  • Peptides / chemistry
  • Peptides / immunology*
  • Porosity
  • RAW 264.7 Cells
  • Silicon Dioxide / chemistry*
  • Silicon Dioxide / immunology
  • Silicon Dioxide / pharmacokinetics
  • Surface Properties

Substances

  • Adjuvants, Immunologic
  • Antibodies
  • Peptides
  • Silicon Dioxide