Cocaine use may induce telomere shortening in individuals with HIV infection

Shenghan Lai; Christopher M Heaphy; Anthony J Rizzo; David D Celentano; Gary Gerstenblith; Ji Li; Richard D Moore; Glenn Treisman; Shaoguang Chen; Parker Foster; Thomas Kickler; Hong Lai

doi:10.1016/j.pnpbp.2018.01.015

Cocaine use may induce telomere shortening in individuals with HIV infection

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):11-17. doi: 10.1016/j.pnpbp.2018.01.015. Epub 2018 Feb 2.

Authors

Affiliations

¹ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: slai@jhmi.edu.
² Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
³ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁴ Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
⁵ Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
⁶ Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Abstract

Background: Although cocaine use may induce/accelerate HIV-associated comorbidities in HIV-infected individuals on antiretroviral therapy (ART), and that HIV itself may accelerate aging, the issue of whether cocaine use plays a role in HIV-associated aging in HIV-infected cocaine users has not been reported. The goals of this study were (1) to explore factor(s) associated with peripheral blood leukocyte telomere length, a marker of cellular replicative history, and telomere shortening in HIV-infected individuals, and (2) to assess whether cocaine use plays a role in accelerating telomere shortening in cocaine users with HIV infection.

Methods: Between June 2010 and December 2016, 147 HIV-infected participants in Baltimore, Maryland, were enrolled in a cross-sectional study investigating factor(s) associated with telomere length. Of these 147, 93 participated in a follow-up study to examine factor(s) associated with telomere shortening. Robust regression model was used to analyze cross-sectional data and the generalized estimating equation approach was used to analyze follow-up data.

Results: Cross-sectional analyses demonstrated that (1) both daily alcohol consumption and use of non-nucleoside reverse transcriptase inhibitors (NNRTIs) were independently associated with telomere length, and cocaine use modified the associations of daily alcohol use and NNRTI use with telomere length. Longitudinal analyses suggested that both daily alcohol consumption and duration of NNRTI use were independently associated with telomere shortening, and (2) cocaine use induced/accelerated telomere shortening in HIV-infected individuals.

Conclusions: Our findings suggest that cocaine use may promote premature aging in HIV-infected individuals who are on ART. Our results emphasize the importance of cocaine abstinence/reduced use, which may retard HIV-associated premature aging.

Keywords: Cocaine use; HIV infection; HIV-associated comorbidities; Premature aging; Telomere length; Telomere shortening.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Cocaine / adverse effects*
Cross-Sectional Studies
Ethanol / adverse effects
Female
HIV Infections / genetics*
Humans
Longitudinal Studies
Male
Middle Aged
Reverse Transcriptase Inhibitors / adverse effects
Telomere Homeostasis / drug effects
Telomere Shortening / drug effects*

Substances

Reverse Transcriptase Inhibitors
Ethanol
Cocaine

Abstract

Publication types

MeSH terms

Substances

Grants and funding