An Intrinsic Interferon Program Protects Stem Cells from Viral Infection

Simon Haas; Andreas Trumpp

doi:10.1016/j.devcel.2018.01.013

An Intrinsic Interferon Program Protects Stem Cells from Viral Infection

Dev Cell. 2018 Feb 5;44(3):279-280. doi: 10.1016/j.devcel.2018.01.013. Epub 2018 Feb 5.

Authors

Simon Haas¹, Andreas Trumpp²

Affiliations

¹ Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
² Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), DKFZ, 69120 Heidelberg, Germany. Electronic address: a.trumpp@dkfz-heidelberg.de.

PMID: 29408233
DOI: 10.1016/j.devcel.2018.01.013

Abstract

Specific protection mechanisms are required to safeguard stem cell integrity. In a recent issue of Cell, Wu et al. (2018) show that stem cells are equipped with high intrinsic expression of interferon-stimulated genes (ISGs) but remain refractory to acute interferon signaling. This protects stem cells from viral infection.

Publication types

Comment

MeSH terms

Humans
Interferons*
Stem Cells*

Substances

Interferons