Association between obesity and bladder cancer recurrence: A meta-analysis

Yadi Lin; Yunyan Wang; Qin Wu; Hua Jin; Gaoxiang Ma; Hanting Liu; Meilin Wang; Zhengdong Zhang; Haiyan Chu

doi:10.1016/j.cca.2018.01.039

Association between obesity and bladder cancer recurrence: A meta-analysis

Clin Chim Acta. 2018 May:480:41-46. doi: 10.1016/j.cca.2018.01.039. Epub 2018 Feb 20.

Authors

Yadi Lin¹, Yunyan Wang², Qin Wu³, Hua Jin⁴, Gaoxiang Ma¹, Hanting Liu¹, Meilin Wang¹, Zhengdong Zhang⁵, Haiyan Chu⁶

Affiliations

¹ Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
² Department of Urology, Huai-an First People's Hospital Affiliated to Nanjing Medical University, Huai-an, China.
³ Department of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, China.
⁴ Core Laboratory of Nantong Tumor Hospital, Nantong, China.
⁵ Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: drzdzhang@njmu.edu.cn.
⁶ Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: chy_grape@njmu.edu.cn.

PMID: 29408169
DOI: 10.1016/j.cca.2018.01.039

Abstract

Background: The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence.

Methods: Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed.

Results: Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36-2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05-1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97-1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02).

Conclusions: This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.

Keywords: Bladder cancer; Obesity; Recurrence; Survival.

Publication types

Meta-Analysis
Review

MeSH terms

Humans
Neoplasm Recurrence, Local / diagnosis*
Obesity / complications
Obesity / diagnosis*
Risk Factors
Urinary Bladder Neoplasms / diagnosis*