CRNDE: An important oncogenic long non-coding RNA in human cancers

Jiaming Zhang; Minuo Yin; Gang Peng; Yingchao Zhao

doi:10.1111/cpr.12440

CRNDE: An important oncogenic long non-coding RNA in human cancers

Cell Prolif. 2018 Jun;51(3):e12440. doi: 10.1111/cpr.12440. Epub 2018 Feb 5.

Authors

Jiaming Zhang^{1

2}, Minuo Yin³, Gang Peng¹, Yingchao Zhao¹

Affiliations

¹ Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Aberrant overexpression of long non-coding RNA CRNDE (Colorectal Neoplasia Differentially Expressed) is confirmed in various human cancers, which is correlated with advanced clinicopathological features and poor prognosis. CRNDE promotes cancer cell proliferation, migration and invasion, and suppresses apoptosis in complicated mechanisms, which result in the initialization and development of human cancers. In this review, we provide an overview of the oncogenic role and potential clinical applications of CRNDE.

Keywords: CRNDE; human cancer; lncRNA; prognosis.

Publication types

Review

MeSH terms

Biomarkers, Tumor / physiology
Carcinogenesis / genetics
Gene Expression Regulation, Neoplastic
Humans
Neoplasms / genetics
Neoplasms / metabolism*
Neoplasms / pathology
Oncogenes
RNA Interference
RNA, Long Noncoding / physiology*

Substances

Biomarkers, Tumor
CRNDE RNA, human
RNA, Long Noncoding