Switching from TNF-induced inflammation to death signaling

Qing Xu; Swati Choksi; Zhengang Liu

doi:10.1080/23723556.2017.1392402

Switching from TNF-induced inflammation to death signaling

Mol Cell Oncol. 2017 Nov 30;5(1):e1392402. doi: 10.1080/23723556.2017.1392402. eCollection 2018.

Authors

Qing Xu¹, Swati Choksi¹, Zhengang Liu¹

Affiliation

¹ Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD, USA.

Abstract

TNFR1-mediated cell signaling involves complex molecular pathways leading to inflammation and death. Cytosolic RARγ plays a pivotal role in converting TNF-induced inflammatory responses to RIP1 initiated cell death and this finely regulated function of RARγ serves as a checkpoint to engage death pathways in response to TNF.

Keywords: Cell death; Mechanisms of oncogenesis and tumor progression; Mechanisms of resistance to therapy; RARg; RIP1; inflammatory signaling; necroptosis.