Non-Covalent Supported of l-Proline on Graphene Oxide/Fe₃O₄ Nanocomposite: A Novel, Highly Efficient and Superparamagnetically Separable Catalyst for the Synthesis of Bis-Pyrazole Derivatives

Molecules. 2018 Feb 5;23(2):330. doi: 10.3390/molecules23020330.

Abstract

A superparamagnetic graphene oxide/Fe₃O₄/l-proline nano hybrid that was obtained from the non-covalent immobilization of l-proline on graphene oxide/Fe₃O₄ nanocomposite was used as a new magnetically separable catalyst for the efficient synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives. The prepared heterogeneous catalyst was characterized using FTIR, TGA, DTG, XRD, TEM, SEM, and elemental analysis techniques. Short reaction times (5-15 min), excellent yields (87-98%), and simple experimental procedure with an easy work-up are some of the advantages of the introduced catalyst.

Keywords: ">l-proline; graphene oxide; heterogeneous catalyst; magnetically separable catalyst; nanocomposite.

MeSH terms

  • Catalysis
  • Ferrosoferric Oxide / chemistry*
  • Graphite / chemistry*
  • Green Chemistry Technology
  • Humans
  • Magnets
  • Molecular Structure
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Oxides
  • Proline / chemistry*
  • Pyrazoles / chemical synthesis*

Substances

  • Oxides
  • Pyrazoles
  • Graphite
  • Proline
  • Ferrosoferric Oxide