Single-institution experience of intensity-modulated radiotherapy for malignant pleural mesothelioma at University of Catania

Future Oncol. 2018 Mar;14(6s):17-21. doi: 10.2217/fon-2017-0280. Epub 2018 Feb 5.

Abstract

The multimodal approach to malignant pleural mesothelioma is gradually becoming the standard of care for this disease in patients with good performance status. Materials & methods: We report our experience concerning eight cases treated with the use of static step-and-shoot intensity-modulated radiotherapy to the whole pleural cavity, in patients already undergoing surgical and/or antiblastic therapy. Results & conclusion: Results at a median follow-up of 16 months showed a median survival from the initial treatment of 29 months, with lung toxicity of grade II reported only in two patients.

Keywords: malignant pleural mesothelioma; multimodal approach; novel therapies; pleural IMRT; radiotherapy; step-and-shoot IMRT; thoracic radiotherapy.

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use
  • Combined Modality Therapy / methods
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Lung / pathology
  • Lung / radiation effects
  • Lung / surgery
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy*
  • Male
  • Mesothelioma / mortality
  • Mesothelioma / pathology
  • Mesothelioma / therapy*
  • Mesothelioma, Malignant
  • Middle Aged
  • Pleura / pathology
  • Pleura / surgery
  • Pleural Neoplasms / mortality
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / therapy*
  • Pneumonectomy / methods
  • Radiation Injuries / epidemiology*
  • Radiation Injuries / etiology
  • Radiotherapy, Intensity-Modulated / adverse effects*
  • Treatment Outcome

Substances

  • Antineoplastic Agents