Daedaleanols A and B, two new sesquiterpenes from cultures of the basidiomycete Daedalea incana

Nat Prod Res. 2019 Jan;33(1):74-79. doi: 10.1080/14786419.2018.1434641. Epub 2018 Feb 4.

Abstract

Two new sesquiterpenes, daedaleanols A (1) and B (2), together with three known sesquiterpenes (3-5), were isolated from cultures of the basidiomycete Daedalea incana. Their structures were elucidated on the basis of extensive spectroscopic means. All compounds were tested for their cytotoxicities against three human cancer cell lines.

Keywords: cytotoxicity; sesquiterpenes.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Basidiomycota / chemistry*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Spectrum Analysis

Substances

  • Antineoplastic Agents
  • Sesquiterpenes