Objective: To study relevant factors that influence psychological resilience in patients with ulcerative colitis(UC), especially the role of perceived stress and personality. Methods: Patients with UC were recruited from January 2015 to December 2016 in the First Hospital of Zhengzhou University. Education levels, income, duration of disease, Mayo score and disease phenotype according to Montreal classification were collected. Resilience was measured using Connor-Davidson resilience scale (CD-RISC). Perceived stress was measured by perceived stress scale (PSS). Personality was evaluated using Eysenck personality questionnaire (EPQ). Univariate analyses were conducted to determine the correlation of variables with resilience and thereafter those statistically significant were reanalyzed via a multivariate regression model. Results: A total of 188 patients with UC were finally recruited. Univariate analyses demonstrated resilience was inversely associated with perceived stress, Mayo score and neuroticism. Extraversion, income, college education were positively related to resilience. However, multivariate analyses revealed that perceived stress(OR=0.901, 95%CI 0.833-0.975), extraversion (OR=1.257, 95%CI 1.087-1.454), neuroticism (OR=0.818, 95%CI 0.679-0.985), Mayo score (OR=0.856, 95%CI 0.742-0.988) and income (OR=6.411, 95%CI 2.136-9.244) were significantly related to resilience. Conclusions: Resilience of UC patients is not only associated with disease activity, but also with personality, perceived stress and income.
目的：探讨主观应激、人格对溃疡性结肠炎(UC)患者心理弹性的影响。 方法：采用横断面现况调查方法，纳入2015年1月—2016年12月在郑州大学第一附属医院消化科就诊的UC患者。收集患者文化程度、收入、病程、Mayo评分、蒙特利尔疾病分型资料，心理弹性评估采用Connor-Davidson心理弹性量表（CD-RISC)，主观应激评估采用主观应激量表(PSS)，人格评估采用艾森克人格问卷(EPQ)。对心理弹性影响因素进行单因素相关分析，对有统计学意义的因素进行多因素logistic回归分析。 结果：入组188例UC患者。单因素相关分析结果提示，心理弹性与主观应激、Mayo评分、神经质呈负相关，与人格外向、经济收入、文化程度呈正相关。多因素相关分析提示心理弹性与以下因素存在关联：主观应激(OR=0.901，95%CI 0.833~0.975)、外向性(OR=1.257，95%CI 1.087~1.454)、神经质(OR=0.818，95%CI 0.679~0.985)、Mayo评分(OR=0.856，95%CI 0.742~0.988)、经济收入(OR=6.411，95%CI 2.136~9.244)。 结论： UC患者的心理弹性不仅与临床疾病病情相关，还与患者的人格、主观应激和经济收入有关。.
Keywords: Colitis, ulcerative; Personality; Resilience, psychological; Stress, psychological.