Novel Insights into NDP52 Autophagy Receptor Functioning

Trends Cell Biol. 2018 Apr;28(4):255-257. doi: 10.1016/j.tcb.2018.01.003. Epub 2018 Jan 31.

Abstract

NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI. Recent studies reveal that Rab35 GTPase controls NDP52 recruitment to its targets and that NDP52 triggers MYOSIN VI (MYO6) motility.

Keywords: NDP52; autophagosome; autophagy receptor; maturation; myosin VI; selective autophagy.

Publication types

  • Review

MeSH terms

  • Autophagosomes / metabolism*
  • Autophagy*
  • Endosomes / metabolism*
  • Humans
  • Lysosomes / metabolism*
  • Models, Biological
  • Myosin Heavy Chains / metabolism
  • Nuclear Proteins / metabolism*
  • Protein Binding
  • rab GTP-Binding Proteins / metabolism

Substances

  • CALCOCO2 protein, human
  • Nuclear Proteins
  • myosin VI
  • RAB35 protein, human
  • Myosin Heavy Chains
  • rab GTP-Binding Proteins