Slow Your Roll: Inhibiting SETD7 Activity Permits Ex Vivo Expansion of Muscle Stem Cells

Ryo Fujita; Colin Crist

doi:10.1016/j.stem.2018.01.007

Slow Your Roll: Inhibiting SETD7 Activity Permits Ex Vivo Expansion of Muscle Stem Cells

Cell Stem Cell. 2018 Feb 1;22(2):146-147. doi: 10.1016/j.stem.2018.01.007.

Authors

Ryo Fujita¹, Colin Crist²

Affiliations

¹ Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada.
² Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada. Electronic address: colin.crist@mcgill.ca.

PMID: 29395050
DOI: 10.1016/j.stem.2018.01.007

Abstract

Muscle stem cell regenerative capacity is rapidly lost during ex vivo culture. In this issue of Cell Stem Cell, Judson et al. (2018) show that inhibition of cytoplasmic SETD7, a lysine methyltransferase, potently expands naive, undifferentiated mouse and human muscle stem cells by restricting their progression through the myogenic program.

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MeSH terms

Animals
Histone-Lysine N-Methyltransferase*
Humans
Mice
Muscle Development*
Myoblasts
Protein Methyltransferases
Stem Cells

Substances

Protein Methyltransferases
Histone-Lysine N-Methyltransferase
SETD7 protein, human
Setd7 protein, mouse