Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission

Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3626-3630. doi: 10.1002/anie.201712528. Epub 2018 Feb 28.

Abstract

Fluorescent probes in the second near-infrared window (NIR-II) allow high-resolution bioimaging with deep-tissue penetration. However, existing NIR-II materials often have poor signal-to-background ratios because of the lack of target specificity. Herein, an activatable NIR-II nanoprobe for visualizing colorectal cancers was devised. This designed probe displays H2 S-activated ratiometric fluorescence and light-up NIR-II emission at 900-1300 nm. By using this activatable and target specific probe for deep-tissue imaging of H2 S-rich colon cancer cells, accurate identification of colorectal tumors in animal models were performed. It is anticipated that the development of activatable NIR-II probes will find widespread applications in biological and clinical systems.

Keywords: colon cancer; fluorescence; in vivo imaging; nanoprobes; second near-infrared window.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Boronic Acids / chemistry
  • Cell Survival / drug effects
  • Colorectal Neoplasms / diagnostic imaging*
  • Cross-Linking Reagents / chemistry
  • Ethanolamines / chemistry
  • Fluorescent Dyes / chemistry*
  • HCT116 Cells
  • Humans
  • Infrared Rays
  • Mice
  • Nanoparticles / chemistry*
  • Optical Imaging / methods
  • Particle Size
  • Silicon Dioxide / chemistry
  • Surface Properties

Substances

  • Boronic Acids
  • Cross-Linking Reagents
  • Ethanolamines
  • Fluorescent Dyes
  • Silicon Dioxide
  • phosphorylethanolamine