New triterpenoids with diverse side-chains from the barks of Melia Toosendan

Fitoterapia. 2018 Jun:127:62-68. doi: 10.1016/j.fitote.2018.01.011. Epub 2018 Jan 31.

Abstract

Nine new euphane- and apotirucallane-type triterpenoids (Toosendines A-I; 1-9), along with three known tirucallane-type compounds were isolated from the barks of Melia toosendan. Their structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and circular dichroism spectra. Results of bioactivities screening exhibited that compounds 1, 4 and 5 showed remarkable NO inhibitory activities in LPS-activated RAW 264.7 macrophages, meanwhile, compounds 1 and 4 showed moderate cytotoxicities against U2OS human cancer cell line.

Keywords: Anti-inflammatory; Circular Dichroism; Cytotoxicity; Ethanol (PubChem CID: 702); Melia toosendan; Methanol (PubChem CID: 887); Methyl cyanide (PubChem CID: 6432); Methylene chloride (PubChem CID: 6344); Triterpenoids.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Cell Line, Tumor
  • Humans
  • Melia / chemistry*
  • Mice
  • Molecular Structure
  • Plant Bark / chemistry*
  • RAW 264.7 Cells
  • Triterpenes / isolation & purification*

Substances

  • Antineoplastic Agents, Phytogenic
  • Triterpenes
  • apotirucallane
  • tirucallane