Nine new euphane- and apotirucallane-type triterpenoids (Toosendines A-I; 1-9), along with three known tirucallane-type compounds were isolated from the barks of Melia toosendan. Their structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and circular dichroism spectra. Results of bioactivities screening exhibited that compounds 1, 4 and 5 showed remarkable NO inhibitory activities in LPS-activated RAW 264.7 macrophages, meanwhile, compounds 1 and 4 showed moderate cytotoxicities against U2OS human cancer cell line.
Keywords: Anti-inflammatory; Circular Dichroism; Cytotoxicity; Ethanol (PubChem CID: 702); Melia toosendan; Methanol (PubChem CID: 887); Methyl cyanide (PubChem CID: 6432); Methylene chloride (PubChem CID: 6344); Triterpenoids.
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