Wnt Signaling in Skeletal Muscle Development and Regeneration

Francesco Girardi; Fabien Le Grand

doi:10.1016/bs.pmbts.2017.11.026

Wnt Signaling in Skeletal Muscle Development and Regeneration

Prog Mol Biol Transl Sci. 2018 Jan:153:157-179. doi: 10.1016/bs.pmbts.2017.11.026. Epub 2018 Jan 8.

Authors

Francesco Girardi¹, Fabien Le Grand²

Affiliations

¹ Sorbonne Universitésy, UPMC Université Paris 06, INSERM UMRS974, Centre of Research in Myology, Paris, France.
² Sorbonne Universitésy, UPMC Université Paris 06, INSERM UMRS974, Centre of Research in Myology, Paris, France. Electronic address: fabien.le-grand@inserm.fr.

PMID: 29389515
DOI: 10.1016/bs.pmbts.2017.11.026

Abstract

Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells. Several studies, within the last decades, showed that several Wnt ligands are involved in myogenesis and both canonical and noncanonical Wnt pathways regulate muscle formation and the maintenance of adult tissue homeostasis. In this review, we provide a comprehensive overview of the roles of Wnt signaling during muscle development and an updated description of Wnt functions during muscle repair. Lastly, we discuss the crosstalk between Wnt and TGFβ signaling pathways in skeletal muscle.

Keywords: Wnt; Wnt/TGFβ crosstalk; muscle regeneration; myofibers; myogenesis; satellite cells; skeletal muscle.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation*
Cell Proliferation
Homeostasis
Humans
Muscle Development / physiology*
Muscle, Skeletal / cytology*
Muscle, Skeletal / metabolism
Regeneration*
Wnt Proteins / metabolism*
Wnt Signaling Pathway*

Substances

Wnt Proteins