"Click" chemistry in polymeric scaffolds: Bioactive materials for tissue engineering

Abstract

Polymeric scaffolds have attracted great interests in recent years, due to their fascination with a large variety of examples with promising utilization. Recently, extensive efforts have been devoted to the exploitation of robust and functional polymer-based biomaterial scaffolds with high efficiency. The recent entry of so-called "click" reactions that include kinds of selective and orthogonal reactions under mild conditions have generated real stimulus not only in preparing elegant bioactive materials of choice but also in making the leap to industrial scale build-up of multifunctional products. In this review paper, we account several kinds of polymeric scaffolds prepared/modified via "click" reactions, with emphasis on their synthetic/functionalized strategies, tunable properties, and biomedical applications.

Keywords: Drug controlled release; Fabrication; Polymeric scaffolds; Tissue engineering; “Click” chemistry.