Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter

Ladie Kimberly C De La Cruz; Stéphane L Benoit; Zhixiang Pan; Bingchen Yu; Robert J Maier; Xingyue Ji; Binghe Wang

doi:10.1021/acs.orglett.7b03348

Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter

Org Lett. 2018 Feb 16;20(4):897-900. doi: 10.1021/acs.orglett.7b03348. Epub 2018 Jan 30.

Authors

Ladie Kimberly C De La Cruz¹, Stéphane L Benoit², Zhixiang Pan¹, Bingchen Yu¹, Robert J Maier², Xingyue Ji¹, Binghe Wang¹

Affiliations

¹ Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303, United States.
² Department of Microbiology, University of Georgia , Athens, Georgia 30602, United States.

PMID: 29380605
DOI: 10.1021/acs.orglett.7b03348

Abstract

A chemical strategy was developed wherein a single trigger sets in motion a three-reaction cascade leading to the release of more than one drug-component in sequence with the generation of a fluorescent side product for easy monitoring. As a proof of concept, codelivery of CO with the antibiotic metronidazole was demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon Monoxide / chemistry*
Fluorescent Dyes
Molecular Structure
Prodrugs

Substances

Fluorescent Dyes
Prodrugs
Carbon Monoxide