Experimental Model of Skeletal Muscle Laceration in Rats

Phablo Abreu; Gabriel Nasri Marzuca-Nassr; Sandro Massao Hirabara; Rui Curi

doi:10.1007/978-1-4939-7614-0_27

Experimental Model of Skeletal Muscle Laceration in Rats

Methods Mol Biol. 2018:1735:397-401. doi: 10.1007/978-1-4939-7614-0_27.

Authors

Phablo Abreu^{1

2}, Gabriel Nasri Marzuca-Nassr³, Sandro Massao Hirabara^{4

5}, Rui Curi^{5

6}

Affiliations

¹ Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil. phabloabreu@usp.br.
² Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil. phabloabreu@usp.br.
³ Department of Internal Medicine, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.
⁴ Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
⁵ Interdisciplinary Post-Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil.
⁶ Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.

PMID: 29380330
DOI: 10.1007/978-1-4939-7614-0_27

Abstract

This is a modified experimental model previously developed in mouse to study skeletal muscle laceration in rats. All experimental procedures are performed during the light period, including anesthesia and surgery. The animals are randomly distributed into control and injured groups prior to the procedure. This experimental model can be used to investigate skeletal muscle laceration repair.

Keywords: Damage; Muscle regeneration; Repair; Skeletal muscle injury; Trauma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Lacerations*
Male
Muscle, Skeletal / injuries*
Muscle, Skeletal / physiology
Rats
Regeneration
Wound Healing