Biological macromolecules for ophthalmic drug delivery to treat ocular diseases

Venkateshwaran Krishnaswami; Ruckmani Kandasamy; Shanmugarathinam Alagarsamy; Rajaguru Palanisamy; Subramanian Natesan

doi:10.1016/j.ijbiomac.2018.01.120

Biological macromolecules for ophthalmic drug delivery to treat ocular diseases

Int J Biol Macromol. 2018 Apr 15:110:7-16. doi: 10.1016/j.ijbiomac.2018.01.120. Epub 2018 Jan 31.

Authors

Venkateshwaran Krishnaswami¹, Ruckmani Kandasamy², Shanmugarathinam Alagarsamy³, Rajaguru Palanisamy⁴, Subramanian Natesan⁵

Affiliations

¹ Department of Pharmaceutical Technology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility on Bioactive Peptides from Milk, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India.
² Department of Pharmaceutical Technology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility for Drug Development, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility on Bioactive Peptides from Milk, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India.
³ Department of Pharmaceutical Technology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India.
⁴ Department of Biotechnology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India.
⁵ Department of Pharmaceutical Technology, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility for Drug Development, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India; National Facility on Bioactive Peptides from Milk, University College of Engineering, BIT Campus, Anna University, Tiruchirappalli, Tamilnadu, India. Electronic address: subramanian.n@aubit.edu.in.

PMID: 29378276
DOI: 10.1016/j.ijbiomac.2018.01.120

Abstract

Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases.

Keywords: Chitosan; Cornea; Macromolecules; Ocular diseases; Ocular drug delivery.

Publication types

Review

MeSH terms

Animals
Drug Carriers / therapeutic use*
Eye Diseases / drug therapy*
Eye Diseases / metabolism
Eye Diseases / pathology
Humans

Substances

Drug Carriers