Meroterpenoids from the fruiting bodies of Ganoderma theaecolum

Qi Luo; Zheng-Chao Tu; Zhu-Liang Yang; Yong-Xian Cheng

doi:10.1016/j.fitote.2018.01.015

Meroterpenoids from the fruiting bodies of Ganoderma theaecolum

Fitoterapia. 2018 Mar:125:273-280. doi: 10.1016/j.fitote.2018.01.015. Epub 2018 Feb 1.

Authors

Qi Luo¹, Zheng-Chao Tu², Zhu-Liang Yang³, Yong-Xian Cheng⁴

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
² Drug Discovery Pipeline & Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Guangzhou 510530, PR China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
⁴ State Key Laboratory of Phytochemistry and Plant Resources in West China, Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, PR China; Henan University of Chinese Medicine, Zhengzhou 450008, PR China. Electronic address: yxcheng@szu.edu.cn.

PMID: 29378219
DOI: 10.1016/j.fitote.2018.01.015

Abstract

A series of new terminal cyclohexane-type meroterpenoids, ganotheaecoloids A-N (1-6, 8-13, 15, and 16), along with three known ones (7, 14, and 17), were isolated from the dried fruiting bodies of Ganoderma theaecolum. Their chemical structures were identified by using spectroscopic data and computational methods. Biological activity of all the new meroterpenoids against COX-2 was evaluated in vitro, only ganotheaecoloid J (11) was found to have COX-2 inhibitory activity with IC₅₀ value of 9.96μM.

Keywords: COX-2; ECD calculations; Ganoderma theaecolum; Ganotheaecoloids A−N; Meroterpenoids.

MeSH terms

Cyclooxygenase Inhibitors / chemistry*
Cyclooxygenase Inhibitors / isolation & purification
Fruiting Bodies, Fungal / chemistry*
Ganoderma / chemistry*
Molecular Structure
Terpenes / chemistry*
Terpenes / isolation & purification

Substances

Cyclooxygenase Inhibitors
Terpenes