1 Joseph R. Kahn Professor, chair of pathology, and director, Medical Scientist Training Program, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio; e-mail: cvh3@cwru.edu; ORCID: http://orcid.org/0000-0002-6333-162X. Professor of physiology and biophysics and director, Medical Scientist Training Program, Albert Einstein College of Medicine, Bronx, New York; ORCID: http://orcid.org/0000-0001-8781-7846. Professor of physiology and biophysics, Weill Cornell Medical College, and director, Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, New York; ORCID: http://orcid.org/0000-0002-3026-6710.