Functional Trajectories, Cognition, and Subclinical Cerebrovascular Disease

Mandip S Dhamoon; Ying-Kuen Cheung; Jose Gutierrez; Yeseon P Moon; Ralph L Sacco; Mitchell S V Elkind; Clinton B Wright

doi:10.1161/STROKEAHA.117.019595

Functional Trajectories, Cognition, and Subclinical Cerebrovascular Disease

Stroke. 2018 Mar;49(3):549-555. doi: 10.1161/STROKEAHA.117.019595. Epub 2018 Jan 26.

Authors

Mandip S Dhamoon¹, Ying-Kuen Cheung², Jose Gutierrez², Yeseon P Moon², Ralph L Sacco², Mitchell S V Elkind², Clinton B Wright²

Affiliations

¹ From the Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY (M.S.D.); Departments of Epidemiology (M.S.V.E.), Biostatistics (Y.-K.C., Y.P.M.), and Neurology, College of Physicians and Surgeons, Mailman School of Public Health (J.G., M.S.V.E.), Columbia University, New York, NY; McKnight Brain Institute (R.L.S.) and Departments of Public Health Sciences and Human Genetics (R.L.S.), Miller School of Medicine, University of Miami, FL; and National Institutes of Health, Bethesda, MD (C.B.W.). mandip.dhamoon@mssm.edu.
² From the Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY (M.S.D.); Departments of Epidemiology (M.S.V.E.), Biostatistics (Y.-K.C., Y.P.M.), and Neurology, College of Physicians and Surgeons, Mailman School of Public Health (J.G., M.S.V.E.), Columbia University, New York, NY; McKnight Brain Institute (R.L.S.) and Departments of Public Health Sciences and Human Genetics (R.L.S.), Miller School of Medicine, University of Miami, FL; and National Institutes of Health, Bethesda, MD (C.B.W.).

Abstract

Background and purpose: Cognition and education influence functional trajectories, but whether associations differ with subclinical brain infarcts (SBI) or white matter hyperintensity volume (WMHV) is unknown. We hypothesized that SBI and WMHV moderated relationships between cognitive performance and education and functional trajectories.

Methods: A total of 1290 stroke-free individuals underwent brain magnetic resonance imaging and were followed for 7.3 years (mean) with annual functional assessments with the Barthel index (range, 0-100). Magnetic resonance imaging measurements included pathology-informed SBI (PI-SBI) and WMHV (% total cranial volume). Generalized estimating equation models tested associations between magnetic resonance imaging variables and baseline Barthel index and change in Barthel index, adjusting for demographic, vascular, cognitive, and social risk factors, and stroke and myocardial infarction during follow-up. We tested interactions among education level, baseline cognitive performance (Mini-Mental State score), and functional trajectories and ran models stratified by levels of magnetic resonance imaging variables.

Results: Mean age was 70.6 (SD, 9.0) years; 19% had PI-SBI, and mean WMHV was 0.68%. Education did not modify associations between cognition and functional trajectories. PI-SBI modified associations between cognition and functional trajectories (P=0.04) with a significant protective effect of better cognition on functional decline seen only in those without PI-SBI. There was no significant interaction for WMHV (P=0.8). PI-SBI, and greater WMHV, were associated with 2- to 3-fold steeper functional decline, holding cognition constant.

Conclusions: PI-SBI moderated the association between cognition and functional trajectories, with 3-fold greater decline among those with PI-SBI (compared with no PI-SBI) and normal baseline cognition. This highlights the strong and independent association between subclinical markers and patient-centered trajectories over time.

Keywords: brain; epidemiology; magnetic resonance imaging; stroke; white matter.

Publication types

Clinical Trial
Multicenter Study
Research Support, N.I.H., Extramural

MeSH terms

Aged
Aged, 80 and over
Brain Infarction* / diagnostic imaging
Brain Infarction* / pathology
Brain Infarction* / physiopathology
Cognition*
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging*
Male
White Matter* / diagnostic imaging
White Matter* / pathology
White Matter* / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding