Abstract
Both melanoma cells and tissues were allowed to interact with an identical pool of billions of human-safe phage nanofiber clones with each genetically displaying a unique 12-mer peptide at the tips, respectively, resulting in the discovery of bionanofibers displaying a melanoma cell/tissue dual-homing peptide for personalized targeted melanoma therapy.
MeSH terms
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Amino Acid Sequence
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Animals
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Bacteriophage M13 / chemistry
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Bacteriophage M13 / metabolism*
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Cell Line, Tumor
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Chlorophyll / analogs & derivatives
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Chlorophyll / therapeutic use
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Drug Carriers / chemistry
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Drug Carriers / metabolism*
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Drug Carriers / pharmacology
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Female
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Humans
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Light
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Melanocytes / metabolism*
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Melanoma / metabolism*
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Melanoma / therapy
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Mice, Inbred BALB C
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Nanofibers / chemistry
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Peptide Library
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Peptides / chemistry
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Peptides / metabolism*
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Peptides / pharmacology
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Photochemotherapy / methods
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Photosensitizing Agents / therapeutic use
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Protein Binding
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Viral Proteins / chemistry
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Viral Proteins / metabolism
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Viral Proteins / pharmacology
Substances
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Drug Carriers
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Peptide Library
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Peptides
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Photosensitizing Agents
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Viral Proteins
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Chlorophyll
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pyropheophorbide a