Evolutionary selection of personalized melanoma cell/tissue dual-homing peptides for guiding bionanofibers to malignant tumors

Chem Commun (Camb). 2018 Feb 8;54(13):1631-1634. doi: 10.1039/c7cc09077c.

Abstract

Both melanoma cells and tissues were allowed to interact with an identical pool of billions of human-safe phage nanofiber clones with each genetically displaying a unique 12-mer peptide at the tips, respectively, resulting in the discovery of bionanofibers displaying a melanoma cell/tissue dual-homing peptide for personalized targeted melanoma therapy.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacteriophage M13 / chemistry
  • Bacteriophage M13 / metabolism*
  • Cell Line, Tumor
  • Chlorophyll / analogs & derivatives
  • Chlorophyll / therapeutic use
  • Drug Carriers / chemistry
  • Drug Carriers / metabolism*
  • Drug Carriers / pharmacology
  • Female
  • Humans
  • Light
  • Melanocytes / metabolism*
  • Melanoma / metabolism*
  • Melanoma / therapy
  • Mice, Inbred BALB C
  • Nanofibers / chemistry
  • Peptide Library
  • Peptides / chemistry
  • Peptides / metabolism*
  • Peptides / pharmacology
  • Photochemotherapy / methods
  • Photosensitizing Agents / therapeutic use
  • Protein Binding
  • Viral Proteins / chemistry
  • Viral Proteins / metabolism
  • Viral Proteins / pharmacology

Substances

  • Drug Carriers
  • Peptide Library
  • Peptides
  • Photosensitizing Agents
  • Viral Proteins
  • Chlorophyll
  • pyropheophorbide a