Antioxidant and Cytoprotective Activity of Oxydiacetate Complexes of Cobalt(II) and Nickel(II) with 1,10-Phenantroline and 2,2'-Bipyridine

Biol Trace Elem Res. 2018 Sep;185(1):244-251. doi: 10.1007/s12011-018-1243-z. Epub 2018 Jan 25.

Abstract

The antioxidant properties of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2'-bipyridine have been investigated towards the superoxide radical using the nitro blue tetrazolium chloride (NBT) test and the cyclic voltammetry (CV). Moreover, the biological activity of the complexes under study has been investigated in the Human Dermal Fibroblasts adult (HDFa) cell line. In the first step, the cytotoxic and the antiproliferative activities of the complexes were examined. Subsequently, the cytoprotective properties of the complexes have been investigated in an oxidative stress conditions induced by H2O2.

Keywords: Cobalt(II) and nickel(II) complexes; Cytoprotective activity; Fibroblasts; Oxidative stress; Oxydiacetate ion.

MeSH terms

  • 2,2'-Dipyridyl / chemistry
  • 2,2'-Dipyridyl / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Cell Line
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Cobalt / chemistry
  • Cobalt / pharmacology*
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • Humans
  • Nickel / chemistry
  • Nickel / pharmacology*
  • Oxidative Stress / drug effects
  • Tetrazolium Salts / pharmacology*

Substances

  • 2,2'-di-4-nitrophenyl-5,5'-diphenyl-3,3'-(3,3'-dimethoxy-4,4'-diphenylene)ditetrazolium
  • Antioxidants
  • Tetrazolium Salts
  • Cobalt
  • 2,2'-Dipyridyl
  • Nickel