Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

Mauryn C Nweke; Anurag S Rathore; Daniel G Bracewell

doi:10.1016/j.tibtech.2018.01.001

Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

Trends Biotechnol. 2018 Oct;36(10):992-995. doi: 10.1016/j.tibtech.2018.01.001. Epub 2018 Jan 20.

Authors

Mauryn C Nweke¹, Anurag S Rathore², Daniel G Bracewell³

Affiliations

¹ Department of Biochemical Engineering, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK.
² Department of Chemical Engineering, IIT Delhi, Hauz Khas, New Delhi, Delhi 110016, India.
³ Department of Biochemical Engineering, University College London, Bernard Katz Building, Gower Street, London WC1E 6BT, UK. Electronic address: d.bracewell@ucl.ac.uk.

PMID: 29370932
DOI: 10.1016/j.tibtech.2018.01.001

Abstract

Poor understanding of the events leading to chromatography column aging makes it difficult to monitor column lifetimes. The lack of established procedures in this area has made it difficult to establish industry standards. Therefore, it is important to understand resin aging mechanisms and techniques to monitor column aging during operation.

Keywords: chromatography resin aging; chromatography resin aging mechanisms; chromatography resin lifetime; fouling characterisation techniques.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products / isolation & purification*
Chromatography / methods*
Laboratory Chemicals*
Technology, Pharmaceutical / methods*
Time Factors

Substances

Biological Products
Laboratory Chemicals