Abstract
A new antibiotic, designated mumiamicin, was isolated from the cultured broth of the rare actinomycete strain, Mumia sp. YSP-2-79, by Diaion HP-20, silica gel and ODS column chromatography, followed by HPLC purification. The chemical structure of mumiamicin was elucidated as a new furan fatty acid by nuclear magnetic resonance and mass spectrometry. Mumiamicin showed antimicrobial activity and antioxidative activity.
Keywords:
antioxidative activity; furan fatty acid; marine actinomycete; mumiamicin; physicochemical screening.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Bacteria / drug effects*
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Chromatography, High Pressure Liquid
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Fatty Acids / chemistry*
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Fatty Acids / isolation & purification
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Fatty Acids / pharmacology
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Fermentation
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Furans / chemistry*
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Furans / isolation & purification
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Furans / pharmacology*
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Magnetic Resonance Spectroscopy
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Nocardiaceae / chemistry*
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Nocardiaceae / classification
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Nocardiaceae / isolation & purification
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Porifera / microbiology
Substances
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Anti-Bacterial Agents
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Antioxidants
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Fatty Acids
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Furans