Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle

Drug Deliv. 2018 Nov;25(1):353-363. doi: 10.1080/10717544.2018.1428241.

Abstract

Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO2-ZrO2/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO2-ZrO2/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.

Keywords: Drug delivery; dual-modal imaging; multifunctional; nanoplatform; theranostic.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry*
  • Drug Delivery Systems / methods
  • Female
  • Gadolinium / chemistry*
  • Hep G2 Cells
  • Humans
  • Magnetic Resonance Imaging / methods
  • Mice, Inbred BALB C
  • Mice, Nude
  • Nanoparticles / chemistry*
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Tomography, X-Ray Computed / methods
  • Zirconium / chemistry*

Substances

  • Polyethylene Glycols
  • Doxorubicin
  • Gadolinium
  • Zirconium

Grants and funding

This work is supported by the Natural Science Foundation of China [Grant No. 61575044, U1505221, 61520106015]; the Science and Technology Infrastructure Construction Program of Fujian Province [Grant No. 2014Y2005]; the Natural Science Foundation of Fujian Province [Grant No. 2014J01389, 2018J01146]; the Scientific Foundation of Fuzhou City [Grant No. 2016-S-124-2].