One-Pot Syntesis of 3-Functionalized 4-Hydroxycoumarin under Catalyst-Free Conditions

Molecules. 2018 Jan 22;23(1):235. doi: 10.3390/molecules23010235.

Abstract

A concise and efficient one-pot synthesis of 3-functionalized 4-hydroxycoumarin derivatives via a three-component domino reaction of 4-hydroxycoumarin, phenylglyoxal and 3-arylaminocyclopent-2-enone or 4-arylaminofuran-2(5H)-one under catalyst-free and microwave irradiation conditions is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.

Keywords: 3-functionalized 4-hydroxycoumarin; catalyst-free; group-assisted purification process; multi-component domino reaction.

MeSH terms

  • 4-Hydroxycoumarins / chemical synthesis*
  • 4-Hydroxycoumarins / chemistry
  • Catalysis
  • Chemistry Techniques, Synthetic*
  • Crystallography, X-Ray
  • Magnetic Resonance Spectroscopy
  • Microwaves
  • Molecular Structure
  • Temperature
  • X-Ray Diffraction

Substances

  • 4-Hydroxycoumarins
  • 4-hydroxycoumarin