Carbapenem-resistant Klebsiella pneumoniae vertebral osteomyelitis in a renal transplant recipient treated with ceftazidime-avibactam

Transpl Infect Dis. 2018 Apr;20(2):e12837. doi: 10.1111/tid.12837. Epub 2018 Feb 19.

Abstract

Ceftazidime-avibactam (CAZ-AVI) is a novel cephalosporin beta lactamase inhibitor combination that has shown activity against carbapenem-resistant Enterobactericeae. Data are limited on its utilization in the treatment of carbapenem-resistant Klebsiella pneumoniae osteomyelitis in solid organ transplant patients. We describe a case report on the use of CAZ-AVI in the treatment of vertebral osteomyelitis in a renal transplant recipient.

Keywords: CRKP; osteomyelitis; renal transplant.

Publication types

  • Case Reports

MeSH terms

  • Amikacin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Azabicyclo Compounds / therapeutic use*
  • Ceftazidime / therapeutic use*
  • Drug Combinations
  • Drug Resistance, Bacterial*
  • Female
  • Humans
  • Kidney Transplantation
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Middle Aged
  • Osteomyelitis / drug therapy
  • Osteomyelitis / microbiology*
  • Postoperative Complications / drug therapy
  • Postoperative Complications / microbiology
  • Spine
  • Transplant Recipients

Substances

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Drug Combinations
  • avibactam, ceftazidime drug combination
  • Amikacin
  • Ceftazidime