Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers

Ryosuke Kasahara; Saiko Kino; Shunsuke Soyama; Yuji Matsuura

doi:10.1364/BOE.9.000289

Noninvasive glucose monitoring using mid-infrared absorption spectroscopy based on a few wavenumbers

Biomed Opt Express. 2017 Dec 20;9(1):289-302. doi: 10.1364/BOE.9.000289. eCollection 2018 Jan 1.

Authors

Ryosuke Kasahara^{1

2}, Saiko Kino³, Shunsuke Soyama², Yuji Matsuura^{2

3}

Affiliations

¹ Ricoh Institute of Information and Communication Technology, Research and Development Division, Ricoh Company, 16-1 Shinei-cho, Yokohama 224-0035, Japan.
² Graduate School of Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan.
³ Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan.

Abstract

A method for performing noninvasive blood glucose measurements was developed. The method is based on mid-infrared absorption spectroscopy and uses only a few wavenumbers to measure blood glucose levels in vivo unconditionally. We found that the regression of blood glucose levels using only three wavenumbers, which were selected using a series cross-validation technique, realized accuracies comparable to those of cases in which a greater number of wavenumbers are used. In addition, we demonstrated the performance of this model through correlations among different types of data.

Keywords: (060.2390) Fiber optics, infrared; (120.3890) Medical optics instrumentation; (300.6300) Spectroscopy, Fourier transforms; (300.6340) Spectroscopy, infrared.