Three new withanolides from the calyces of Nicandra physaloides

Qin Xiao; Cui-Fang Wang; Jun Chen; Chen-Lei Lian; Ying Xu; Lei Xiao; Jie-Qing Liu

doi:10.1016/j.steroids.2018.01.003

Three new withanolides from the calyces of Nicandra physaloides

Steroids. 2018 Mar:131:32-36. doi: 10.1016/j.steroids.2018.01.003.

Authors

Qin Xiao¹, Cui-Fang Wang², Jun Chen¹, Chen-Lei Lian¹, Ying Xu¹, Lei Xiao¹, Jie-Qing Liu³

Affiliations

¹ School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China.
² College of Oceanology and Food Science, ‬Quanzhou Normal University, ‬Quanzhou 362000, ‬China.
³ School of Biomedical Sciences, Huaqiao University, Quanzhou 362021, China; Engineering Research Center of Molecular Medicine, Xiamen 361021, ‬China. Electronic address: liujieqing@hqu.edu.cn.

PMID: 29355564
DOI: 10.1016/j.steroids.2018.01.003

Abstract

Chemical investigation on ethyl acetate extract of the calyces of Nicandra physaloides resulted in the isolation of three new withanolides named as nicphysatone A (1), nicphysatone B (2), nicphysatone C (3), together with five known withanolides, nic 17 (4), nic 7 (5), nic 2 (6), withahisolide G (7) and nicaphysalin B (8). The structures were determined by comprehensive spectroscopic experiments. The discovery enriched the diversity of natural withanolides and could serve as scaffolds for the synthesis of more potent modified withanolides.

Keywords: Nicandra physaloides; Nicphysatones A-C; Solanaceae; Steroids; Withanolides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Flowers / chemistry*
Humans
Solanaceae / chemistry*
Withanolides / chemistry
Withanolides / isolation & purification*
Withanolides / pharmacology*

Substances

Antineoplastic Agents
Withanolides