Sparks fly between ascorbic acid and iron-based nanozymes: A study on Prussian blue nanoparticles

Wei Zhang; Yang Wu; Hai-Jiao Dong; Jun-Jie Yin; Hui Zhang; Hao-An Wu; Li-Na Song; Yu Chong; Zhuo-Xuan Li; Ning Gu; Yu Zhang

doi:10.1016/j.colsurfb.2018.01.010

Sparks fly between ascorbic acid and iron-based nanozymes: A study on Prussian blue nanoparticles

Colloids Surf B Biointerfaces. 2018 Mar 1:163:379-384. doi: 10.1016/j.colsurfb.2018.01.010. Epub 2018 Jan 11.

Authors

Wei Zhang¹, Yang Wu², Hai-Jiao Dong³, Jun-Jie Yin⁴, Hui Zhang⁴, Hao-An Wu³, Li-Na Song⁵, Yu Chong⁴, Zhuo-Xuan Li³, Ning Gu⁶, Yu Zhang⁷

Affiliations

¹ State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210096, PR China; The Jiangsu Province Research Institute for Clinical Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, PR China.
² Research Centre of Clinical Oncology, Jiangsu Cancer Hospital, Nanjing 210009, PR China.
³ State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China.
⁴ Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA.
⁵ Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, PR China.
⁶ State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210096, PR China. Electronic address: guning@seu.edu.cn.
⁷ State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210096, PR China. Electronic address: zhangyu@seu.edu.cn.

PMID: 29353215
DOI: 10.1016/j.colsurfb.2018.01.010

Abstract

Herein we reported Prussian blue nanoparticles (PBNPs) possess ascorbic acid oxidase (AAO)- and ascorbic acid peroxidase (APOD)-like activities, which suppressed the formation of harmful H₂O₂ and finally inhibited the anti-cancer efficiency of ascorbic acid (AA). This newly revealed correlation between iron and AA could provide new insight for the studies of nanozymes and free radical biology.

Keywords: Anti-cancer efficiency; Ascorbic acid oxidase; Electron spin resonance; Peroxidase; Prussian blue nanoparticles.

MeSH terms

Ascorbate Oxidase / metabolism*
Ascorbate Peroxidases / metabolism*
Ascorbic Acid / chemistry*
Catalysis
Ferrocyanides / chemistry*
Humans
Iron / chemistry*
MCF-7 Cells
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Oxidation-Reduction

Substances

Ferrocyanides
Iron
Ascorbate Oxidase
Ascorbate Peroxidases
Ascorbic Acid
ferric ferrocyanide