In spite of the progress in the cyclodextrins chemistry, the synthesis of monodisperse derivatives with a defined degree of substitution is still a challenge. In this work we present a novel dendritic material produced by combining βCD and second generation poly(ester) dendrons. The selective attachment of dendrons in the seven positions of the βCD-primary face was performed through a CuAAC click reaction, which along with a very simple work-up, allowed obtaining the monodisperse material in very high yields. The product showed a great aqueous solubility and an in vitro non-toxic profile. The enhanced complexation potential of the product was evidenced through the formation of an inclusion complex with albendazole, which presented a Kc = 29636.17 M-1. In this system, albendazole was 45 times more water-soluble in comparison to the complex albendazole-native βCD. All these features make the dendritic material very attractive for further applications in the formulation and drug delivery fields.
Keywords: Click chemistry; Inclusion complex; Poly(ester) dendrons; β-Cyclodextrin.
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