Cryptococcus gattii genotype VGIIa infection imported from Vancouver Island to Japan

Tsuyoshi Kitaura; Masamichi Takahashi; Takashi Umeyama; Nozomi Takeshita; Yuichi Katanami; Saho Takaya; Kei Yamamoto; Satoshi Kutsuna; Kayoko Hayakawa; Yasuyuki Kato; Takahiro Yamauchi; Yoshitaka Narita; Yoshitsugu Miyazaki; Norio Ohmagari

doi:10.1016/j.jiac.2017.12.014

Cryptococcus gattii genotype VGIIa infection imported from Vancouver Island to Japan

J Infect Chemother. 2018 Jul;24(7):573-575. doi: 10.1016/j.jiac.2017.12.014. Epub 2018 Jan 17.

Affiliations

¹ Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
² Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
³ Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
⁴ Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. Electronic address: nozomitake@gmail.com.

PMID: 29352650
DOI: 10.1016/j.jiac.2017.12.014

Abstract

A 71-year-old Japanese man with travel history to the Vancouver Island, Canada was diagnosed the pulmonary and central nervous system infections caused by Cryptococcus gattii genotype VGIIa. This is the first imported case of Cryptococcus gattii genotype VGIIa infection from endemic area of North America to Japan. He was recovery with no residual neurological dysfunction by early resection of brain mass and antifungal therapy. Early surgical resection of cerebellar cryptococcoma may shorten the length of induction therapy with antifungal drugs.

Keywords: Cryptococcosis; Cryptococcus gattii; Japan; Surgery; Travel; Vancouver Island.

Publication types

Case Reports

MeSH terms

Aged
Antifungal Agents / therapeutic use
Antigens, Fungal / blood
Antigens, Fungal / cerebrospinal fluid
Canada
Central Nervous System Fungal Infections / drug therapy
Central Nervous System Fungal Infections / microbiology*
Central Nervous System Fungal Infections / surgery
Computed Tomography Angiography
Cryptococcosis / drug therapy
Cryptococcosis / microbiology*
Cryptococcus gattii / classification
Cryptococcus gattii / genetics*
Cryptococcus gattii / isolation & purification
Genotype
Humans
Japan
Lung Diseases, Fungal / drug therapy
Lung Diseases, Fungal / microbiology*
Magnetic Resonance Imaging
Male
Multilocus Sequence Typing
Radiography
Sequence Analysis, DNA

Substances

Antifungal Agents
Antigens, Fungal