Dual energy computed tomography should be a first line preoperative localization imaging test for primary hyperparathyroidism patients

Abstract

Background: The objective of this study was to evaluate the performance of dual-energy computed tomography (DECT) for preoperative parathyroid tumor (PT) localization in primary hyperparathyroid (PHP) patients.

Methods: A retrospective review was carried out of the medical records of all PHP patients who underwent ultrasound (US), Tc-99m sestamibi noncontrast single photon emission computed tomography (CT-MIBI), DECT and parathyroidectomy at a single center.

Results: The sensitivities and accuracies for preoperative PT localization in the 97 patient study population were: US 40% and 93%, CT-MIBI 64.0% and 97%, and DECT 84% and 96%, respectively. In the one third of the study population that did not localize preoperatively with CT-MIBI and US, DECT correctly localized a PT in 21 cases (66%). DE-CT and US correctly localized a PT in 86% of cases, and only 5 (8%) of the cases that were accurately localized by a combination of CT-MIBI and US were not identified by DE-CT.

Conclusions: DECT should be utilized as a first line preoperative PT localization study in PHP patients, and is also a sensitive salvage localization test.

Keywords: Dual energy CT; Localization studies; Parathyroid; Primary hyperparathyroidism; Sestamibi scan; Ultrasound.