Abstract
Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.
Keywords:
clinical characteristics; coronavirus; influenza-like illness.
© 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
Publication types
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Multicenter Study
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Observational Study
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Aged
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Alphacoronavirus / classification
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Alphacoronavirus / genetics
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Alphacoronavirus / isolation & purification*
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Alphacoronavirus / pathogenicity
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Betacoronavirus / classification
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Betacoronavirus / genetics
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Betacoronavirus / isolation & purification*
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Betacoronavirus / pathogenicity
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Coronavirus Infections / pathology*
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Coronavirus Infections / virology*
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Female
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Gastrointestinal Diseases / pathology
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Gastrointestinal Diseases / virology
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Humans
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Longitudinal Studies
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Male
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Middle Aged
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Polymerase Chain Reaction
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RNA, Viral / genetics
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Respiratory Tract Infections / complications
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Respiratory Tract Infections / pathology*
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Respiratory Tract Infections / virology*
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Young Adult