Recent developments in the synthesis and applications of dihydropyrimidin-2(1H)-ones and thiones

Behzad Mohammadi; Farahnaz K Behbahani

doi:10.1007/s11030-017-9806-z

Recent developments in the synthesis and applications of dihydropyrimidin-2(1H)-ones and thiones

Mol Divers. 2018 May;22(2):405-446. doi: 10.1007/s11030-017-9806-z. Epub 2018 Jan 18.

Authors

Behzad Mohammadi¹, Farahnaz K Behbahani²

Affiliations

¹ Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran.
² Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran. farahnazkargar@yahoo.com.

PMID: 29349521
DOI: 10.1007/s11030-017-9806-z

Abstract

Dihydropyrimidin-2(1H)-ones/thiones (DHPMs) are important heterocyclic compounds owing to their excellent biological activities and have been widely utilized in pharmaceutical applications. Recently, numerous DHPM derivatives have been prepared. This review covers the synthesis of DHPMs and improved procedures for the preparation of DHPMs from 1995 to 2016.

Keywords: DHPMs; Dihydropyrimidin-2(1H)-ones; Dihydropyrimidin-2(1H)-ones/thiones; MCRs; Multicomponent reaction; Three-component reaction.

Publication types

Review

MeSH terms

Chemistry Techniques, Synthetic / methods*
Pyrimidinones / chemical synthesis*
Pyrimidinones / chemistry*
Solvents / chemistry
Thiones / chemical synthesis*
Thiones / chemistry*

Substances

Pyrimidinones
Solvents
Thiones