Effects of tetrahedral DNA nanostructures on autophagy in chondrocytes

Chem Commun (Camb). 2018 Feb 1;54(11):1327-1330. doi: 10.1039/c7cc09397g.

Abstract

Tetrahedral DNA nanostructures (TDNs) have gathered great attention and are being widely used in biomedicine. We demonstrated that autophagy increased after exposure to TDNs (250 nM) along with the up-regulation of several autophagy-related genes and proteins. TDNs enhanced cell autophagy through the PI3K/AKT/mTOR signaling pathway.

MeSH terms

  • Animals
  • Autophagy / drug effects*
  • Autophagy / genetics
  • Carbocyanines / chemistry
  • Chondrocytes / metabolism*
  • DNA / chemistry
  • DNA / metabolism*
  • Fluorescence
  • Fluorescent Dyes / chemistry
  • Mice
  • Nanostructures*
  • Rats
  • Signal Transduction / drug effects
  • Up-Regulation / drug effects

Substances

  • Carbocyanines
  • Fluorescent Dyes
  • cyanine dye 5
  • DNA