Replication timing kept in LINE

Rachel J O'Neill; Michael J O'Neill

doi:10.1083/jcb.201712173

Replication timing kept in LINE

J Cell Biol. 2018 Feb 5;217(2):441-443. doi: 10.1083/jcb.201712173. Epub 2018 Jan 18.

Authors

Rachel J O'Neill^{1

2}, Michael J O'Neill^{3

2}

Affiliations

¹ Institute for Systems Genomics, University of Connecticut, Storrs, CT Rachel.oneill@uconn.edu.
² Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT.
³ Institute for Systems Genomics, University of Connecticut, Storrs, CT.

Abstract

Accurate and synchronous replication timing between chromosome homologues is essential for maintaining chromosome stability, yet how this is achieved has remained a mystery. In this issue, Platt et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201707082) identify antisense LINE (L1) transcripts within long noncoding RNAs as the critical factor in maintaining synchronous chromosome-wide replication timing.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Chromosomes
DNA Replication Timing
RNA, Antisense*
RNA, Long Noncoding*
Retroelements

Substances

RNA, Antisense
RNA, Long Noncoding
Retroelements