Potential Role of MicroRNA in the Anabolic Capacity of Skeletal Muscle With Aging

Exerc Sport Sci Rev. 2018 Apr;46(2):86-91. doi: 10.1249/JES.0000000000000147.

Abstract

Age-induced loss of skeletal muscle mass and function, termed sarcopenia, may be the result of diminished response to anabolic stimulation. This review will explore the hypothesis that alterations in the expression of microRNA with aging contributes to reduced muscle plasticity resulting in impaired skeletal muscle adaptations to exercise-induced anabolic stimulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological
  • Aging / metabolism*
  • Gene Expression
  • Humans
  • MicroRNAs / blood
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Muscle Proteins / biosynthesis*
  • Muscle, Skeletal / metabolism*
  • Resistance Training*
  • Sarcopenia / metabolism
  • Sarcopenia / prevention & control
  • Signal Transduction

Substances

  • MicroRNAs
  • Muscle Proteins