The purpose of this study was to comprehensively characterize a little-known polypore that has recently been found to possess anticancer activity and thus can also be used in targeted cancer therapy. Earliella scabrosa is a polypore with pantropical distribution and can be found in rainforests in both the Eastern and Western Hemispheres. Some reports have described its antioxidant properties and free radical scavenging ability. Moreover, isocoumarin, which has been successfully used in targeted cancer therapy, was found in extracts of this fungus. We recommend further research of E. scabrosa so that more details of its health benefits could be used in mycotherapy.