Hexim1, an RNA-controlled protein hub

Transcription. 2018;9(4):262-271. doi: 10.1080/21541264.2018.1429836. Epub 2018 Feb 23.

Abstract

Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It was initially described as a non-coding RNA-dependent regulator of transcription. Here, we detail how 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). In addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets.

Keywords: 7SK; CDK9; NEAT1; P-TEFb; eukaryotic transcription; innate immunity; melanoma; nucleotide depletion; transcription regulation; transcriptional elongation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunity, Innate
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism*
  • RNA-Binding Proteins / immunology
  • RNA-Binding Proteins / metabolism*
  • Transcription Factors
  • Transcription, Genetic / drug effects
  • Transcription, Genetic / genetics

Substances

  • HEXIM1 protein, human
  • RNA, Long Noncoding
  • RNA-Binding Proteins
  • Transcription Factors
  • long non-coding RNA 7SK, human

Grants and funding

This work was supported by grants Agence Nationale pour la Recherche [grant number ANR 10-LABX-54 MEMOLIFE] and [grant number ANR-11-IDEX-0001-02 PSL*] Research University.