A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length

Cheng-Yuan Gu; Gao-Xiang Li; Yu Zhu; Hua Xu; Yao Zhu; Xiao-Jian Qin; Dai Bo; Ding-Wei Ye

doi:10.7150/jca.21774

A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length

J Cancer. 2018 Jan 1;9(2):269-274. doi: 10.7150/jca.21774. eCollection 2018.

Authors

Cheng-Yuan Gu^{1

2}, Gao-Xiang Li^{1

2}, Yu Zhu^{1

2}, Hua Xu^{1

2}, Yao Zhu^{1

2}, Xiao-Jian Qin^{1

2}, Dai Bo^{1

2}, Ding-Wei Ye^{1

2}

Affiliations

¹ Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
² Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Abstract

BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is a key enzyme in its oestrogen metabolism pathway, giving rise to hydroxylation and conjugation. Functionally relevant genetic variants within CYP1B1 may affect the telomere length and subsequently lead to prostate carcinogenesis. METHODS: We evaluated 8 CYP1B1 tag single nucleotide polymorphisms (SNPs) in 1015 men with prostate cancer (PCa) and 1052 cancer-free controls, and calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate their association with risk of PCa. The influence of CYP1B1 SNPs on the relative telomere lengths was then appraised in peripheral blood leukocytes using real-time PCR. RESULTS:CYP1B1 rs1056836 variant was associated with decreased risk of PCa [odds ratio (OR): 0.80; 95% confidence interval (CI): 0.68-0.99, P = 0.041]. Longer telomere length showed a significantly higher proportion of the CYP1B1 rs1056836 CG/GG genotypes, compared with that of the CC genotype (OR: 1.60, 95% CI: 1.04-2.45). CONCLUSION: Our findings suggest that genetic variants within CYP1B1 may confer genetic susceptibility to PCa by altering telomere length.

Keywords: CYP1B1; prostate cancer; single nucleotide polymorphism; susceptibility..