New Job for NK Cells: Architects of the Tumor Microenvironment

Lydia Dyck; Lydia Lynch

doi:10.1016/j.immuni.2018.01.001

New Job for NK Cells: Architects of the Tumor Microenvironment

Immunity. 2018 Jan 16;48(1):9-11. doi: 10.1016/j.immuni.2018.01.001.

Authors

Lydia Dyck¹, Lydia Lynch²

Affiliations

¹ School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
² School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA. Electronic address: llynch@bwh.harvard.edu.

PMID: 29343443
DOI: 10.1016/j.immuni.2018.01.001

Abstract

NK cells control tumor growth directly through targeted cytotoxic granule release or cytokine secretion and indirectly by orchestrating anti-tumor immune responses. In this issue of Immunity, Glasner et al. (2018) now reveal a new role for NK cells in preventing metastatic spread through controlling tumor architecture.

Publication types

Comment

MeSH terms

Cytoplasmic Granules
Humans
Killer Cells, Natural*
Neoplasms
Tumor Microenvironment*