In Vivo Pharmacokinetics of Magnetic Nanoparticles

Carlos Caro; M Carmen Muñoz-Hernández; Manuel Pernia Leal; María Luisa García-Martín

doi:10.1007/978-1-4939-7531-0_24

In Vivo Pharmacokinetics of Magnetic Nanoparticles

Methods Mol Biol. 2018:1718:409-419. doi: 10.1007/978-1-4939-7531-0_24.

Authors

Carlos Caro¹, M Carmen Muñoz-Hernández¹, Manuel Pernia Leal², María Luisa García-Martín^{3

4}

Affiliations

¹ BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain.
² Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla, Sevilla, Spain.
³ BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Junta de Andalucía, Universidad de Málaga, Málaga, Spain. mlgarcia@bionand.es.
⁴ Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Málaga, Spain. mlgarcia@bionand.es.

PMID: 29341022
DOI: 10.1007/978-1-4939-7531-0_24

Abstract

Over the past few years, many papers have been published on the nanomedical applications of magnetic nanoparticles. However, most studies lack important information about the in vivo behavior of these nanoparticles, which is a critical aspect for their rational design. In this chapter we describe a simple protocol for the in vivo characterization of the pharmacokinetics of magnetic nanoparticles intravenously injected in mice, using basic MRI sequences.

Keywords: CPMG; Dynamic T2-weighted MRI; Magnetic nanoparticles; Pharmacokinetics; Relative enhancement; T2 mapping.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media / pharmacokinetics*
Magnetic Resonance Imaging / methods*
Magnetite Nanoparticles / administration & dosage*
Magnetite Nanoparticles / chemistry*
Mice
Tissue Distribution

Substances

Contrast Media
Magnetite Nanoparticles