Biomedical 19F MRI Using Perfluorocarbons

Tuba Güden-Silber; Sebastian Temme; Christoph Jacoby; Ulrich Flögel

doi:10.1007/978-1-4939-7531-0_14

Biomedical ¹⁹F MRI Using Perfluorocarbons

Methods Mol Biol. 2018:1718:235-257. doi: 10.1007/978-1-4939-7531-0_14.

Authors

Tuba Güden-Silber¹, Sebastian Temme¹, Christoph Jacoby¹, Ulrich Flögel²

Affiliations

¹ Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.
² Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany. floegel@uni-duesseldorf.de.

PMID: 29341012
DOI: 10.1007/978-1-4939-7531-0_14

Abstract

Background-free fluorine (¹⁹F) MR imaging exhibits an excellent degree of specificity, and facilitates among others the in vivo visualization of inflammatory processes. Merging¹⁹F MR images with morphologically matching¹H MR images enables the exact anatomic localization of the observed¹⁹F signal. Biochemically inert nanoemulsions of perfluorocarbons, which are known to be taken up by the macrophage/monocyte system, are widely used as contrast agents for preclinical applications. Herein, the most common protocols are described to obtain high-resolution and artifact-free¹⁹F MR images even for compounds with complex¹⁹F MR spectra. In addition, we report on the utilization of perfluorocarbons with individual spectral identities and targeting approaches to specifically visualize thrombi by¹⁹F MRI.

Keywords: Active targeting; Chemical shift imaging; Fluorine MRI; Perfluorocarbons; Sterol-based post-insertion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Fluorine Radioisotopes
Fluorocarbons*
Image Processing, Computer-Assisted / methods*
Inflammation / diagnosis*
Magnetic Resonance Imaging / methods*
Mice

Substances

Fluorine Radioisotopes
Fluorocarbons