Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

Chem Commun (Camb). 2018 Jan 31;54(10):1237-1240. doi: 10.1039/c7cc09130c.

Abstract

Expanding the chemical diversity of threose nucleic acid (TNA) beyond the natural bases would enable the development of TNA polymers with enhanced physicochemical properties. Here, we describe a versatile approach for increasing the chemical diversity of TNA using 5-alkynyl-modified α-l-threofuranosyl uridine triphosphates that are substrates for a TNA polymerase.

MeSH terms

  • DNA-Directed DNA Polymerase / metabolism*
  • Nucleic Acids / chemistry*
  • Nucleic Acids / metabolism*
  • Substrate Specificity
  • Tetroses / chemistry*
  • Uridine Triphosphate / analogs & derivatives*
  • Uridine Triphosphate / chemistry
  • Uridine Triphosphate / metabolism*

Substances

  • Nucleic Acids
  • Tetroses
  • DNA-Directed DNA Polymerase
  • Uridine Triphosphate