The large defect of oral and maxillofacial region doesn't only affect the function and aesthetics but also has an adverse impact on patients' psychology. The traditional way to restore the defects are limited by donor site and secondary trauma. In recent years,the oral mucosal tissue engineering has developed rapidly and provides a new solution for craniofacial reconstruction. Tissue-engineered oral mucosa is an ideal substitute of oral mucosa. It can be used in clinical settings and in vitro experiments. This articles review the recent advances in tissue-engineered oral mucosa and its applications.
口腔及颌面部的大面积组织缺损会影响口腔功能和面部美观,而目前传统的修复方法存在供区组织有限及二次创伤等不足。近些年,组织工程黏膜得到迅猛发展,为修复口腔颌面部组织缺损提供了新的解决途径。组织工程黏膜是理想的人体黏膜组织替代物,除了应用于体内修复组织缺损,还可以用作体外实验的研究模型。本文主要综述组织工程黏膜研究的最新进展与应用。.